Cetuximab for treating non-small cell lung cancer
نویسندگان
چکیده
منابع مشابه
Cetuximab and biomarkers in non-small-cell lung carcinoma
Cancer progression is a highly complex process that is driven by a constellation of deregulated signaling pathways and key molecular events. In non-small-cell lung cancer (NSCLC), as in several other cancer types, the epidermal growth factor receptor (EGFR) and its downstream signaling components represent a key axis that has been found not only to trigger cancer progression but also to support...
متن کاملWeekly cetuximab and gemcitabine plus cisplatin as salvage therapy for unresectable non-small cell lung cancer.
after 4 months of treatment (fig. 1 and 2), and was evaluated as resectable. With the patient’s permission, a left upper lobectomy (LUL) with superior segmentectomy via left thoracotomy was performed on 19 February 2008, and the pathological diagnosis was mucoepidermoid carcinoma stage T2N1. Further adjuvant chemotherapy with the same regimen was given for another 3 months. Presently in March 2...
متن کاملA review of clinical trials of cetuximab combined with radiotherapy for non-small cell lung cancer
Treatment of non-small cell lung cancer (NSCLC) is challenging in many ways. One of the problems is disappointing local control rates in larger volume disease. Moreover, the likelihood of both nodal and distant spread increases with primary tumour (T-) stage. Many patients are elderly and have considerable comorbidity. Therefore, aggressive combined modality treatment might be contraindicated o...
متن کاملIs there a role for cetuximab in non small cell lung cancer?
The epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC). In addition, activating mutations in the EGFR tyrosine kinase domain have been described almost exclusively in NSCLC. Cetuximab, a monoclonal antibody against EGFR, has only modest single-agent activity in advanced NSCLC. A few phase II studies conducted in advanced NSCLC show no signifi...
متن کاملSentinel Node Mapping in Non-small Cell Lung Cancer Using an Intraoperative Radiotracer Technique
Objective(s): Lymph node metastases are the most significant prognostic factor in localized non-small cell lung cancer (NSCLC). Identification of the first nodal drainage site (sentinel node) may improve detection of metastatic nodes. Extended surgeries, such as lobectomy or pneumonectomy with lymph node dissection, are among the therapeutic options of higher acceptab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Opinion on Biological Therapy
سال: 2018
ISSN: 1471-2598,1744-7682
DOI: 10.1080/14712598.2018.1452906